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The Science Behind De-Extinction

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The idea of de-extinction is that we can bring back species that are now completely gone. The major flashpoint of interest in what has now led to de-extinction technology happened about 10 years ago when Dolly the sheep was created. In many ways, Dolly was the harbinger of the kind of technology that will permit us to do even more sophisticated kinds of creation of species that used to exist, species that still exist and perhaps even species that never existed. We can group relevant methods into three large categories.There's back-breeding which humans have practiced literally for thousands and thousands of years. This is being done right now in Western Europe, trying to recreate what's known as the aurochs. The way cows look today is not the way the cattle family looked 10,000 years ago. So, if your problem is to recreate one of those primitive cows, what do you do? Well you reach back into the genetic code by selecting for animals that have slightly longer horns or a bigger bulk or the kind of hide coloration that you think is appropriate. It is a very viable and low-tech way of de-extinction. And the investigators trying to do this back-breeding to aurochs have had some success. The animals look quite a bit like old representations that go right back to cave paintings. But what is it really? What it is really is a constellation of traits that you've selected for and you know nothing, really, about how close it is physiologically to an aurochs because there's no way of examining a living aurochs at present. You also don't know about behavior. Behavior tends not to fossilize in any realistic manner and the degree to which any modern cow resembles an aurochs in terms of behavior is a complete unknown. A second method for de-extinction that has improved greatly in the last 10 years is cloning, particularly the kind of cloning known as somatic cell nuclear transfer. You take the genetic material -- the nucleus -- of one cell, you put it into another -- an egg -- and that egg is then placed in an animal that will act as surrogate mother and produce an offspring. There's also been massive improvements in what we can call synthesis. Synthesis involves making up our own sequence, just like in a recipe. If you have two species -- one extinct, one living -- you can get the genetic material of the extinct one and compare that to the living one. Passenger pigeons died out, finally, almost exactly a hundred years ago. Passenger pigeons have several very close relatives among pigeons and one is the band-tailed pigeon, which is very close indeed.  In recent years, scientists have been able to isolate the differences between the genomes of extinct passenger pigeons and living band-tailed pigeons. They've been able to inject these novel sequences into the germ line of developing band-tailed pigeons and using surrogates with the sex cells of passenger pigeons.If you cross breed them one to another, you will in the next generation get something that should look exactly like a passenger pigeon. Now comes the basic question here, which is: What are you going to do with passenger pigeons, assuming that you go ahead and create a whole flock of them? It's been estimated that there were probably more passenger pigeons than any other kind of bird ever. I don't know what we would do with a billion passenger pigeons. We don't like pigeons to begin with in this place. A very important thing to consider about extinctions in general in the course of life on the planet is that the waters close very quickly when a species disappears. What tends to happen is that other species move in. This is how evolution in fact works. The mammoth behind me perfectly illustrates some of the issues that we're going to face with de-extinction. There is no place for several more very large herbivores in a place like the U.S. except under very controlled conditions. Who's going to take care of them? How are you going to provision them? Are we thinking that we're going to bring back the Pleistocene by virtue of having a few extinct species? What we're really talking about is undertaking a whole lot of unplanned experiments, the consequences of which are very hard to predict. We don't want a situation in which we drive out species that are perhaps already endangered thanks to us with something else that we drove to extinction thousands of years ago. De-extinction to the degree it will take place should be limited in its scope, limited in its ambition, limited in the kinds of species that we bring back. But if there was one animal I could vote for to bring back, it would be one of these giant ground sloths. If you want people to be interested in not only what the planet still has and how we might conserve it, but what the planet has recently lost and perhaps most particularly what it's lost because of human activities, then to see these again, to see mammoths again in the flesh would be an exciting prospect. It would raise rather than dampen interest in preserving what we have and what we used to have. Video Link: https://youtu.be/Pkc_WodJxsk

Major flashpoint. sophisticated De-Extinction Completely gone Might bring back species aTechnology Dolly the sheep. 10 years ago Harbinger Kind of technology  Kind of creation of species Species that still exist  Species that never existed Three large Categories Back-breeding Western Europe The aurochs Cows Looked Cattle Family 10,000 year ago Primitive cows Genetic code Constellation Physiologically Fossilize Cloning Genetic material. The nucleus  The one cell Synthesis Cequence One exinct Passenger pigeons Developing Surrogates Billion passenger pigeons Mammoth Large herbivores Pleistocene Consequences Pleistocene Giant ground sloths Particularly Exciting prospect Dampen.